Solving mitochondrial mysteries
نویسندگان
چکیده
منابع مشابه
Post Mortem - Solving History's Great Medical Mysteries
We are fascinated by other people's problems; we are fascinated by celebrity-and when celebrities have problems, the effect is synergistic, rather than additive. This is not merely the province of tabloids and daytime television-serious scholars crave their fix of morbid gossip too. Historical diagnosis has a long and juicy history, and in " Post Mortem " , Mackowiak revisits some of the most c...
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Medically unexplained symptoms and chronic functional syndromes are common but few healthcare professionals have had formal training about their connection to psychosocial issues. A systematic approach to diagnosis and treatment based on experience with over 7000 of these patients is described. Outcomes improve with assessment for and treatment of current life stresses, the prolonged impact of ...
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Compared to sperm nuclei, nuclei from adult somatic cells replicate inefficiently in frog egg extract. In this issue of Cell, Lemaitre et al. (2005) show that pre-exposure of erythrocyte nuclei to a mitotic extract removes this difference, reorganizes the chromatin into shorter loops, and allows replication at much shorter intervals along the DNA. Remarkably, these observations also explain an ...
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The psychological autopsy is an important assessment tool used to identify aspects of a person's life that explain any lingering mystery that shrouds their death. In addition to answering questions of the past, the psychological autopsy has significant implications for the future. Statistics obtained from mortality data affect the course of health care research, the flow of resources, and ultim...
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Mitochondrial diseases cause a range of clinical manifestations even in patients carrying the same mtDNA mutations. New work reveals that a common disease-associated mtDNA mutation is selectively segregated from wild-type mtDNA during the reprogramming of induced pluripotent stem cells and that high levels of this mutation in differentiated neurons upregulate Parkin-mediated mitophagy.
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2015
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2014.11.016